diff --git a/package/python-lmdb/Config.in b/package/python-lmdb/Config.in
index baf9bce5ac..b63af96ec4 100644
--- a/package/python-lmdb/Config.in
+++ b/package/python-lmdb/Config.in
@@ -1,6 +1,5 @@
 config BR2_PACKAGE_PYTHON_LMDB
 	bool "python-lmdb"
-	select BR2_PACKAGE_PYTHON_CFFI # runtime
 	help
 	  Universal Python binding for the LMDB 'Lightning' Database.
 
diff --git a/package/python-lmdb/python-lmdb.hash b/package/python-lmdb/python-lmdb.hash
index ad176d5d21..064c76fb58 100644
--- a/package/python-lmdb/python-lmdb.hash
+++ b/package/python-lmdb/python-lmdb.hash
@@ -1,5 +1,5 @@
 # md5, sha256 from https://pypi.org/pypi/lmdb/json
-md5  d216e0220c625aa72de2acc158e81a0e  lmdb-1.4.1.tar.gz
-sha256  1f4c76af24e907593487c904ef5eba1993beb38ed385af82adb25a858f2d658d  lmdb-1.4.1.tar.gz
+md5  bdd78148e8374cb0001af06cc64bfefb  lmdb-1.5.1.tar.gz
+sha256  717c255827d331e02f7242b44051aa06466c90f6d732ecb07b31edfb1e06c67a  lmdb-1.5.1.tar.gz
 # Locally computed sha256 checksums
 sha256  310fe25c858a9515fc8c8d7d1f24a67c9496f84a91e0a0e41ea9975b1371e569  LICENSE
diff --git a/package/python-lmdb/python-lmdb.mk b/package/python-lmdb/python-lmdb.mk
index 7906d388ae..7105fd1464 100644
--- a/package/python-lmdb/python-lmdb.mk
+++ b/package/python-lmdb/python-lmdb.mk
@@ -4,14 +4,13 @@
 #
 ################################################################################
 
-PYTHON_LMDB_VERSION = 1.4.1
+PYTHON_LMDB_VERSION = 1.5.1
 PYTHON_LMDB_SOURCE = lmdb-$(PYTHON_LMDB_VERSION).tar.gz
-PYTHON_LMDB_SITE = https://files.pythonhosted.org/packages/de/13/dd9b0c1924f0becc93e0bacd123a4e7a347966e3e74753ace3b1e85acc39
+PYTHON_LMDB_SITE = https://files.pythonhosted.org/packages/67/2c/0cc9375341121ca1f4b31a2137f955dc24550e095d733c9b42ea94113ba1
 PYTHON_LMDB_LICENSE = OLDAP-2.8
 PYTHON_LMDB_LICENSE_FILES = LICENSE
 PYTHON_LMDB_CPE_ID_VENDOR = py-lmdb_project
 PYTHON_LMDB_CPE_ID_PRODUCT = py-lmdb
 PYTHON_LMDB_SETUP_TYPE = setuptools
-PYTHON_LMDB_DEPENDENCIES = host-python-cffi
 
 $(eval $(python-package))