diff --git a/package/qt5/qt5webkit/qt5webkit.mk b/package/qt5/qt5webkit/qt5webkit.mk
index 2e96acc00f..6401c39d3d 100644
--- a/package/qt5/qt5webkit/qt5webkit.mk
+++ b/package/qt5/qt5webkit/qt5webkit.mk
@@ -42,6 +42,10 @@ ifeq ($(BR2_PACKAGE_LIBEXECINFO),y)
 QT5WEBKIT_DEPENDENCIES += libexecinfo
 endif
 
+ifeq ($(BR2_TOOLCHAIN_USES_MUSL),y)
+QT5WEBKIT_CONF_OPTS += -DENABLE_SAMPLING_PROFILER=OFF
+endif
+
 QT5WEBKIT_CONF_OPTS += \
 	-DENABLE_TOOLS=OFF \
 	-DPORT=Qt \