diff --git a/package/webkitgtk/webkitgtk.mk b/package/webkitgtk/webkitgtk.mk
index 65a4439839..b760a1f2bf 100644
--- a/package/webkitgtk/webkitgtk.mk
+++ b/package/webkitgtk/webkitgtk.mk
@@ -108,9 +108,12 @@ endif
 # have a check for these processors. Disable JIT forcibly here and use
 # the CLoop interpreter instead.
 #
+# Also, we have to disable the sampling profiler, which does NOT work
+# with ENABLE_C_LOOP.
+#
 # Upstream bug: https://bugs.webkit.org/show_bug.cgi?id=191258
 ifeq ($(BR2_MIPS_CPU_MIPS32R6)$(BR2_MIPS_CPU_MIPS64R6),y)
-WEBKITGTK_CONF_OPTS += -DENABLE_JIT=OFF -DENABLE_C_LOOP=ON
+WEBKITGTK_CONF_OPTS += -DENABLE_JIT=OFF -DENABLE_C_LOOP=ON -DENABLE_SAMPLING_PROFILER=OFF
 endif
 
 $(eval $(cmake-package))