diff --git a/package/pkg-python.mk b/package/pkg-python.mk
index 38bc45ffa3..52c33f8752 100644
--- a/package/pkg-python.mk
+++ b/package/pkg-python.mk
@@ -28,6 +28,7 @@ PKG_PYTHON_DISTUTILS_ENV = \
 	LDFLAGS="$(TARGET_LDFLAGS)" \
 	LDSHARED="$(TARGET_CROSS)gcc -shared" \
 	PYTHONPATH="$(if $(BR2_PACKAGE_PYTHON3),$(PYTHON3_PATH),$(PYTHON_PATH))" \
+	PYTHONNOUSERSITE=1 \
 	_python_sysroot=$(STAGING_DIR) \
 	_python_prefix=/usr \
 	_python_exec_prefix=/usr
@@ -43,7 +44,8 @@ PKG_PYTHON_DISTUTILS_INSTALL_STAGING_OPTS = \
 
 # Host distutils-based packages
 HOST_PKG_PYTHON_DISTUTILS_ENV = \
-	PATH=$(BR_PATH)
+	PATH=$(BR_PATH) \
+	PYTHONNOUSERSITE=1
 
 HOST_PKG_PYTHON_DISTUTILS_INSTALL_OPTS = \
 	--prefix=$(HOST_DIR)/usr
@@ -52,6 +54,7 @@ HOST_PKG_PYTHON_DISTUTILS_INSTALL_OPTS = \
 PKG_PYTHON_SETUPTOOLS_ENV = \
 	PATH=$(BR_PATH) \
 	PYTHONPATH="$(if $(BR2_PACKAGE_PYTHON3),$(PYTHON3_PATH),$(PYTHON_PATH))" \
+	PYTHONNOUSERSITE=1 \
 	_python_sysroot=$(STAGING_DIR) \
 	_python_prefix=/usr \
 	_python_exec_prefix=/usr
@@ -70,7 +73,8 @@ PKG_PYTHON_SETUPTOOLS_INSTALL_STAGING_OPTS = \
 
 # Host setuptools-based packages
 HOST_PKG_PYTHON_SETUPTOOLS_ENV = \
-	PATH=$(BR_PATH)
+	PATH=$(BR_PATH) \
+	PYTHONNOUSERSITE=1
 
 HOST_PKG_PYTHON_SETUPTOOLS_INSTALL_OPTS = \
 	--prefix=$(HOST_DIR)/usr