diff --git a/package/matio/matio.mk b/package/matio/matio.mk
index d282852d37..1370b32edf 100644
--- a/package/matio/matio.mk
+++ b/package/matio/matio.mk
@@ -15,6 +15,14 @@ MATIO_INSTALL_STAGING = YES
 # va_copy()
 MATIO_CONF_ENV = ac_cv_va_copy=yes
 
+MATIO_CFLAGS = $(TARGET_CFLAGS)
+
+ifeq ($(BR2_TOOLCHAIN_HAS_GCC_BUG_99410),y)
+MATIO_CFLAGS += -O0
+endif
+
+MATIO_CONF_ENV += CFLAGS="$(MATIO_CFLAGS)"
+
 # mat73 require hdf5 (not available), extented-sparse take 2KB
 MATIO_CONF_OPTS = --disable-mat73 --enable-extended-sparse