diff --git a/package/exim/exim.mk b/package/exim/exim.mk
index 5e9746af4d..482c7ca2c1 100644
--- a/package/exim/exim.mk
+++ b/package/exim/exim.mk
@@ -104,6 +104,7 @@ define EXIM_CONFIGURE_TOOLCHAIN
 	$(call exim-config-add,HOSTCFLAGS,$(HOSTCFLAGS))
 	$(call exim-config-add,EXTRALIBS,$(EXIM_EXTRALIBS))
 	$(EXIM_FIX_IP_OPTIONS_FOR_MUSL)
+	$(EXIM_DISABLE_VALGRIND)
 endef
 
 ifneq ($(call qstrip,$(BR2_PACKAGE_EXIM_CUSTOM_CONFIG_FILE)),)
@@ -154,6 +155,13 @@ else ifeq ($(BR2_TOOLCHAIN_USES_GLIBC),)
 EXIM_CFLAGS = -DNO_EXECINFO
 endif
 
+# src/valgrind.h contains inline asm not compatible with thumb1
+ifeq ($(BR2_ARM_INSTRUCTIONS_THUMB),y)
+define EXIM_DISABLE_VALGRIND
+	$(call exim-config-change,NVALGRIND,1)
+endef
+endif
+
 # We need the host version of macro_predef during the build, before
 # building it we need to prepare the makefile.
 define EXIM_BUILD_CMDS