diff --git a/package/python-tpm2-pytss/Config.in b/package/python-tpm2-pytss/Config.in
index 60d9e8b9d3..dec9a311d4 100644
--- a/package/python-tpm2-pytss/Config.in
+++ b/package/python-tpm2-pytss/Config.in
@@ -1,6 +1,7 @@
 config BR2_PACKAGE_PYTHON_TPM2_PYTSS
 	bool "python-tpm2-pytss"
 	depends on !BR2_STATIC_LIBS # tpm2-tss
+	depends on BR2_PACKAGE_HOST_RUSTC_TARGET_ARCH_SUPPORTS # python-cryptography
 	select BR2_PACKAGE_PYTHON_ASN1CRYPTO # runtime
 	select BR2_PACKAGE_PYTHON_CFFI # runtime
 	select BR2_PACKAGE_PYTHON_CRYPTOGRAPHY # runtime
@@ -11,4 +12,5 @@ config BR2_PACKAGE_PYTHON_TPM2_PYTSS
 	  https://github.com/tpm2-software/tpm2-pytss
 
 comment "python-tpm2-pytss needs a toolchain w/ dynamic library"
+	depends on BR2_PACKAGE_HOST_RUSTC_TARGET_ARCH_SUPPORTS
 	depends on BR2_STATIC_LIBS