diff --git a/utils/genrandconfig b/utils/genrandconfig
index 727c8193c4..8437d6342d 100755
--- a/utils/genrandconfig
+++ b/utils/genrandconfig
@@ -124,6 +124,13 @@ async def fixup_config(sysinfo, configfile):
     if 'BR2_PACKAGE_LIBOPENSSL=y\n' in configlines and \
        'BR2_TOOLCHAIN_HAS_ATOMIC=y\n' not in configlines:
         return False
+    # Qemu in user mode cannot load target binaries laid out for 4k
+    # pages on a host with larger pages (e.g. 16k on Apple Silicon),
+    # so packages running target code at build time (gobject-
+    # introspection, nodejs) fail there.
+    if 'BR2_PACKAGE_HOST_QEMU_LINUX_USER_MODE=y\n' in configlines and \
+       os.sysconf('SC_PAGE_SIZE') > 4096:
+        return False
     if 'BR2_PACKAGE_SUNXI_BOARDS=y\n' in configlines:
         configlines.remove('BR2_PACKAGE_SUNXI_BOARDS_FEX_FILE=""\n')
         configlines.append('BR2_PACKAGE_SUNXI_BOARDS_FEX_FILE="a10/hackberry.fex"\n')