diff --git a/package/python-grpcio/Config.in b/package/python-grpcio/Config.in
index 6119991c7e..f52e19dc18 100644
--- a/package/python-grpcio/Config.in
+++ b/package/python-grpcio/Config.in
@@ -6,6 +6,11 @@ config BR2_PACKAGE_PYTHON_GRPCIO_ARCH_SUPPORTS
 	default y if BR2_i386 || BR2_x86_64
 	default y if BR2_mips || BR2_mipsel || BR2_mips64 || BR2_mips64el
 	default y if BR2_riscv
+	# The bundled abseil-cpp only implements DirectMmap() for the o32
+	# ABI on MIPS, and its 64-bit fallback fails to build with the n32
+	# ABI, where long is 32-bit. See
+	# third_party/abseil-cpp/absl/base/internal/direct_mmap.h
+	depends on !BR2_MIPS_NABI32
 
 config BR2_PACKAGE_PYTHON_GRPCIO
 	bool "python-grpcio"